Chronic Myelocytic Leukemia in Identical Twins

C group trisomy in identical twins with acute leukemia.

Two Techniques of Tonsillectomy Performed in Identical Twins: A Case Report

Introduction:Cold dissection (CD) and bipolar cautery dissection (BCD) techniques are two common surgical tonsillectomy procedures used in the clinic. Obstruction has become more prevalent as the major surgical indication and is most prominently observed in younger children.Case Report:  In this report, we aimed to explain the abovementioned surgical techniques in detail and compare the results...

Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero.

We report a pair of identical twins with concordant acute lymphoblastic leukemia (ALL). Unusually, their diagnoses were spaced 9 years apart at ages 5 and 14. Leukemic cells in both twins had a TEL-AML1 rearrangement, which was characterized at the DNA level by an adaptation of a long distance polymerase chain reaction (PCR) method. The genomic fusion sequence was identical in the two leukemias...

Acute myeloid leukaemia in one of identical twins.

Joseph Needham' has recently observed that ' progress in science consists not so much of finding the right answers to certain definite and sensible questions, as of deciding what questions are sensible, and of making them definite.' In clinical medicine this is as a rule by no means easy, for cases occur in a haphazard manner in populations subjected to a variety of external influences which wi...

BIRC5 Gene Disruption via CRISPR/Cas9n Platform Suppress Acute Myelocytic Leukemia Progression

Background: Acute myelocytic leukemia (AML) is a clonal malignancy resulting from the accumulation of genetic abnormalities in the cells. Human baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5), encodes survivin, is one of only a handful of genes that is differentially over-expressed in numerous malignant diseases including AML. Methods: The BIRC5 was silenced permanently in two AM...